BDBM50201227 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile::CHEMBL391738::SKS-927

SMILES COc1cc(Nc2c(cnc3cc(C#CCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key InChIKey=ZJDFSJYCAFMEGH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50201227   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of Src activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 73nMAssay Description:Inhibition of Src in rat fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 720nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201227(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed