BDBM50137565 1-((2R,6S,9aR)-6-Phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one::CHEMBL51972::SR-14136

SMILES O=c1[nH]c2ccccc2n1[C@@H]1CCN2[C@H](CCC[C@H]2c2ccccc2)C1

InChI Key InChIKey=KMUYAJQKQQUKSQ-UHFFFAOYSA-N

Data  4 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50137565   

TargetKappa-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human opioid receptor kappa 1 using [3H]- U-69,593 as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataEC50:  4.70nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human opioid receptor kappa 1 in cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for human opioid receptor mu 1 using [3H]- DAMGO as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataKi:  5.70nMAssay Description:Ability to displace [125I]-Tyr14 at nociceptin (NOP) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataEC50:  65nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human NOP receptor in cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataEC50:  198nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human opioid receptor mu 1 in cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50137565(SR-14136 | 1-((2R,6S,9aR)-6-Phenyl-octahydro-quino...)
Affinity DataKi:  1.72E+3nMAssay Description:Binding affinity for human opioid receptor delta 1 using [3H]- CL-DPDPE as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed