BDBM50370682 SOLIFENACIN

SMILES [H]C12CCN(CC1)C[C@@H]2OC(=O)N1CCc2ccccc2[C@@H]1c1ccccc1

InChI Key InChIKey=FBOUYBDGKBSUES-VXKWHMMOSA-N

Data  8 KI  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50370682   

TargetMuscarinic acetylcholine receptor M1(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  10nMAssay Description:Binding affinity for rat cortex muscarinic acetylcholine receptor M1 using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  10nMAssay Description:Binding affinity for rat salivary gland muscarinic acetylcholine receptor M3 using [3H]N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]NMS from recombinant human muscarinic M3 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M5(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]NMS from recombinant human muscarinic M5 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]NMS from recombinant human muscarinic M1 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  120nMAssay Description:Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataKi:  129nMAssay Description:Displacement of [3H]NMS from recombinant human muscarinic M4 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  270nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataEC50:  24nMAssay Description:Antagonist activity at M3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  251nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed