BDBM50155929 CHEMBL225157::TAK-242

SMILES CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl

InChI Key InChIKey=LEEIJTHMHDMWLJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50155929   

TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of IL-6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of NO productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of TNF-alpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 680nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed