BDBM50017103 9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenylimino)-2,3,6,7-tetrahydro-pyrimido[6,1-a]isoquinolin-4-one::9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenylimino)-2,3,6,7-tetrahydro-pyrimido[6,1-a]isoquinolin-4-one.HCl::CHEMBL285913::Trequinsin

SMILES COc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC

InChI Key InChIKey=MCMSJVMUSBZUCN-YYDJUVGSSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50017103   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50:  3.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50:  1.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed