BDBM50412494 CHEMBL452847::VUF-10497

SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1

InChI Key InChIKey=OLJSGKYQYTWQNJ-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50412494   

TargetHistamine H4 receptor(Human)
Griffin Discoveries

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Griffin Discoveries

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Griffin Discoveries

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  7.60nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2026
Entry Details PCBioAssay
TargetHistamine H4 receptor(Rat)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  15.8nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  19.9nMAssay Description:Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Griffin Discoveries

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2017
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Griffin Discoveries

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataIC50: 69.2nMAssay Description:Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412494BDBM50412494(VUF-10497 | CHEMBL452847 | US12492199, Example 3Q)
Affinity DataKi:  550nMAssay Description:Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2017
Entry Details Article
PubMed