BDBM464015 US10787435, Example 005::WX005

SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-n1cnc(c1)C1CC1

InChI Key InChIKey=YRDYYBPBINZIEC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 464015   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM464015(WX005 | US10787435, Example 005)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM464015(WX005 | US10787435, Example 005)
Affinity DataIC50: 50nMAssay Description:Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent