BDBM50201099 4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide::CHEMBL216272::ZK-216348

SMILES Cc1noc(=O)c2ccc(NC(=O)C(O)(CC(C)(C)c3cccc4CCOc34)C(F)(F)F)cc12

InChI Key InChIKey=VRZVKIJRJRBQJT-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50201099   

TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of tetramethylrhodamine labeled dexamethosone binding to MR by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  6.31nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced coll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataEC50:  12.6nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells assessed as induction of MMTV promoter activity by luciferase reporter gene a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  19.9nMAssay Description:Binding affinity to human recombinant progesterone receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  79.4nMAssay Description:Binding affinity to human recombinant mineralocorticoid receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Human)
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  631nMAssay Description:Binding affinity to human recombinant androgen receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  31.6nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-8...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)
Affinity DataIC50:  19.9nMAssay Description:Binding affinity to human recombinant glucocorticoid receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed