BDBM50164644 2',3'-Dideoxyadenosine Triphosphate (Ddatp)::2',3'-dideoxyadenosine triphosphate::ATP,2',3'-dideoxy::CHEMBL1383::[[[5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid::ddA-TP::ddATP

SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1

InChI Key InChIKey=OAKPWEUQDVLTCN-NKWVEPMBSA-N

Data  8 KI  2 IC50  1 Kd

PDB links: 15 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50164644   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  50nMAssay Description:Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  75.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  90nMAssay Description:Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 3(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  406nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptase (RT M184V)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  510nMAssay Description:Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptase (RT M184I)More data for this Ligand-Target Pair
TargetDNA polymerase beta(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKd:  5.30E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed