BDBM50307794 2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propanamide::CHEMBL596757::ibu-am5 (2)

SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C

InChI Key InChIKey=ZBKGVYYUEQPQPO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50307794   

TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umeå University

LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  520nMpH: 7.0 T: 2°CAssay Description:Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umeå University

LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  650nMpH: 7.0 T: 2°CAssay Description:Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umeå University

LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of sheep COX2 pre-incubated for 5 mins before anandamide acid substrate addition by peroxidase activity detection based oxygen electrode a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umeå University

LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of sheep COX1 pre-incubated for 5 mins before arachidonic acid substrate addition in presence of DMSO by peroxidase activity detection bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umeå University

LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  500nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat cerebellum membranes pre-incubated for 10 mins before addition of [3H]AEA substrate in presence of ethyl alc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50307794(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of sheep COX1 pre-incubated for 5 mins before arachidonic acid substrate addition in presence of ethanol by peroxidase activity detection ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed