BDBM50063300 (L-N6-1-iminoethyl)lysine::(S)-6-Acetimidoylamino-2-amino-hexanoic acid::6-Acetimidoylamino-2-amino-hexanoic acid::CHEMBL1744034::CHEMBL7889::L-N6-(1-iminoethyl)lysine::N~6~-[(1Z)-ethanimidoyl]-L-lysine::l-NIL

SMILES CC(N)=NCCCC[C@H](N)C(O)=O

InChI Key InChIKey=ONYFNWIHJBLQKE-ZETCQYMHSA-N

Data  1 KI  37 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50063300   

TargetNitric oxide synthase, inducible(Mouse)
University At Buffalo

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataKi:  2.16E+3nMAssay Description:The compound was tested for competitive antagonist of Nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  4.70E+8nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.84E+4nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  130nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  6.10E+4nMAssay Description:Compound was evaluated for the Inhibition of Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  3.80E+4nMAssay Description:Compound was evaluated for the Inhibition of endothelial isoform of Endothelial nitric oxide synthase (eNOS)enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was evaluated for the Inhibition of induced isoform of Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rat)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  2.40E+3nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  2.40E+3nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Rat)
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  9.20E+4nMAssay Description:Tested for inhibition of rat brain inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mouse)
University At Buffalo

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  3.30E+3nMAssay Description:Tested for inhibition of mouse inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  6.10E+4nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.38E+5nMAssay Description:Inhibitory activity against human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.38E+5nMAssay Description:The concentration required for inhibition of Human endothelial nitric oxide synthase (eNOS) isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  5.90E+3nMAssay Description:The concentration required for inhibition of Human inducible nitric oxide synthase (iNOS) isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  3.50E+4nMAssay Description:The concentration required for inhibition of Human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibitory activity against Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition concentration against Neuronal nitric oxide synthase (nNOS) at 10 uM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.38E+5nMAssay Description:Inhibition concentration against Endothelial nitric oxide synthase (eNOS) at 10 uM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  4.90E+3nMAssay Description:InInhibition concentration against Inducible nitric oxide synthase (iNOS) at 10 uM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory activity against human endothelial nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against human neuronal nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human nNOS expressed in insect SF9 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human iNOS expressed in human DLD1 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human eNOS expressed in insect SF9 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  6.17E+4nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Searle

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed