BDBM50056999 CHEMBL56367::nimesulide
SMILES CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
InChI Key InChIKey=HYWYRSMBCFDLJT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 48 hits for monomerid = 50056999
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
3D Structure (crystal)TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataKi: 1.51E+4nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
Affinity DataKi: 7.00E+4nMAssay Description:Mixed type inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate preinc...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 1.30E+3nMAssay Description:The inhibitory activity against cyclooxygenase Prostaglandin G/H synthase 2 (COX-2) measured as PGE-2 production after blood coagulation using human ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 700nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 600nMAssay Description:In vitro inhibition activity against cyclooxygenase 2 with the compound dissolved in DMSOMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of aromatase in SK-BR-3 cells by tritiated water release assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 5 to 10 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 2.31E+5nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cellMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of ovine COX1 assessed as PGF2alpha level by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of ovine COX2 assessed as PGF2alpha level by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human myeloperoxidaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 700nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of human COX2 expressed in baculovirus infected sf21 cells assessed as reduction in formation of oxidized TMPD using arachidonic acid as s...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrateMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 700nMAssay Description:Inhibition of COX-2 in human whole blood assessed as PGE2 level in plasma after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of COX-1 in human whole blood assessed as thromboxane B2 level in serum after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate readerMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of LTA4 hydrolase in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 0.5 hrs by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 23nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 1.74E+4nMAssay Description:In vitro inhibition activity against cyclooxygenase 1 with the compound dissolved in DMSOMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 2.20E+4nMAssay Description:The inhibitory activity against Prostaglandin G/H synthase 1 measured as TXB2 production after blood coagulation using human Whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 15nMAssay Description:Inhibitory activity of the compound was evaluated against human Prostaglandin G/H synthase 2 was determinedMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibitory activity of the compound was evaluated against human Prostaglandin G/H synthase 1 was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair