BDBM103826 SPI-01::US11041859, Code SPI-01::US9791447, Compound SPI-01

SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O

InChI Key InChIKey=ANGMGEOZQHWOBK-NKPXSSHVSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 103826   

TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  3.28E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 3(Homo sapiens)TBA
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of SENP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.88E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.10E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  5.90E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  2.90E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  3.50E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  3.28E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.42E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSmall ubiquitin-related modifier 1/2(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.88E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 2(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  5.90E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  2.90E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  3.50E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of SENP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.42E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed