BDBM103826 SPI-01::US11041859, Code SPI-01::US9791447, Compound SPI-01
SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O
InChI Key InChIKey=ANGMGEOZQHWOBK-NKPXSSHVSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 103826
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 3.28E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of SENP3 (unknown origin)More data for this Ligand-Target Pair
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 1.88E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 1.10E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 5.90E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 2.90E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
TargetSentrin-specific protease/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope
US Patent
City of Hope
US Patent
Affinity DataIC50: 3.28E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
TargetSentrin-specific protease 2/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope
US Patent
City of Hope
US Patent
Affinity DataIC50: 1.42E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
Affinity DataIC50: 1.88E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
TargetSentrin-specific protease/Small ubiquitin-related modifier 2(Homo sapiens (Human))
City of Hope
US Patent
City of Hope
US Patent
Affinity DataIC50: 1.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 5.90E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 2.90E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of SENP2 (unknown origin)More data for this Ligand-Target Pair
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope
Beckman Research Institute of The City of Hope
Affinity DataIC50: 1.42E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair