BDBM104524 US8575201, 15

SMILES CN(C)c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1

InChI Key InChIKey=NFSSFVUKSIEQIF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 104524   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104524(US8575201, 15)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104524(US8575201, 15)
Affinity DataIC50: 280nMAssay Description:Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104524(US8575201, 15)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as reduction in LTB4 production pretreated for 15 mins followed by calcimycin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed