BDBM105064 US8569281, 9

SMILES C1CC(CCO1)Nc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

InChI Key InChIKey=QOUDVGHKRPBIKE-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 105064   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Medical Research Council Technology

US Patent
LigandPNGBDBM105064(US8569281, 9)
Affinity DataKi:  27nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Medical Research Council Technology

US Patent
LigandPNGBDBM105064(US8569281, 9)
Affinity DataKi:  27nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in insect cells using RtGWWRFYTLRRAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Medical Research Council Technology

US Patent
LigandPNGBDBM105064(US8569281, 9)
Affinity DataIC50:  135nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed