BDBM106698 CHEMBL1957349::US8586620, 42

SMILES CN1CCC(=CC1)c1c[nH]c2ccc(cc12)N=C(N)c1cccs1

InChI Key InChIKey=LHMBGXCQBZFVCE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 106698   

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  920nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  5.11E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  2.00E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  51nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  190nMAssay Description:Inhibition of human nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  2.24E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human iNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  160nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent