BDBM106921 US8592455, 121

SMILES C[C@H]1C[C@H](C[C@@H](O)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F

InChI Key InChIKey=TXAQYFMSBSSETH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106921   

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM106921(US8592455, 121)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandPNGBDBM106921(US8592455, 121)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM106921(US8592455, 121)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
Go to US Patent