BDBM10778 3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl N-ethyl-N-methylcarbamate hydrochloride::Aminoindan deriv. 21b::N-propargylaminoindan 21b

SMILES CCN(C)C(=O)Oc1cccc2CCC(NCC#C)c12

InChI Key InChIKey=CPURZAVPYKEGDF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10778   

TargetAcetylcholinesterase(Homo sapiens (Human))
Teva Pharmaceutical Industries

LigandPNGBDBM10778(3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...)
Affinity DataIC50:  5.25E+4nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10778(3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10778(3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Teva Pharmaceutical Industries

LigandPNGBDBM10778(3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...)
Affinity DataIC50:  310nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed