BDBM116762 US8637532, 476

SMILES CN1CCN(CC1)c1ccc(cc1C(F)(F)F)C(=O)Nc1cccc(CNc2nncc3c(cccc23)C(N)=O)c1

InChI Key InChIKey=ZCNHSWBTKSJQNS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116762   

TargetAurora kinase A(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 116762BDBM116762(US8637532, 476)
Affinity DataIC50: 3.40nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase B(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 116762BDBM116762(US8637532, 476)
Affinity DataIC50: 5.80nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 116762BDBM116762(US8637532, 476)
Affinity DataIC50: 61nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 116762BDBM116762(US8637532, 476)
Affinity DataIC50: 8.20E+4nMpH: 7.5 T: 2°CAssay Description:The kinase assay is performed as 384-well Flashplate assay (PerkinElmer LAS Germany GmbH). 3.4 nM His6-PDK1(Delta 1-50) (PDK1 that has a His-tag cons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent