BDBM117306 US8653087, II-5

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncnc2c(N)nc(NCc3cccnc3)nc12

InChI Key InChIKey=VPBTVKDGTJQKOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117306   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM117306(US8653087, II-5)
Affinity DataIC50: 50nMpH: 7.5Assay Description:The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
Go to US Patent