BDBM117315 US8653087, II-14

SMILES CN1CCC(CN2CCN(CC2)c2nc(N)c3ncnc(Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)c3n2)CC1

InChI Key InChIKey=XFMKDNKSJYLMGH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117315   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM117315(US8653087, II-14)
Affinity DataIC50: 4nMpH: 7.5Assay Description:The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
US Patent