BDBM117519 US8653087, III-199

SMILES COc1c(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(nc34)N(C)CCN(C)C)c2)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key InChIKey=APRLZYSRWACYES-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117519   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM117519(US8653087, III-199)
Affinity DataIC50: 23nMpH: 7.5Assay Description:The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
Go to US Patent