BDBM11859 2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]ethyl}propanamide::5-mercapto-1,3,4-thiadiazole 13b

SMILES CC(NC(=O)C(Cc1ccccc1)NC(=O)NS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1nnc(S)s1

InChI Key InChIKey=IKFXTEOZLBAELL-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 11859   

TargetNeutrophil collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  100nMAssay Description:Inhibition of human MMP-8 assessed as inhibition constant using AcProLeuGly-S-LeuLeuGlyOEt as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  100nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi Di Firenze

LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  200nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColH(Hathewaya histolytica)
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  200nMAssay Description:Inhibition of Clostridium histolyticum CoLH assessed as inhibition constant using M MOCAcPro-Leu-Gly-Leu-A2pr-(DNP)Ala-Arg-NH2 as substrate incubated...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  300nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human MMP-2 assessed as inhibition constant using AcProLeuGly-S-LeuLeuGlyOEt as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM11859(2-({[(4-fluorobenzene)sulfonyl]carbamoyl}amino)-3-...)
Affinity DataKi:  1.20E+4nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed