BDBM11879 N-Hydroxy-1-(methylsulfonyl)-4-{[4-(phenoxyphenyl]-sulfonyl}piperidine-4-carboxamide::N-hydroxy-1-methanesulfonyl-4-[(4-phenoxybenzene)sulfonyl]piperidine-4-carboxamide::alpha-sulfone 27i

SMILES CS(=O)(=O)N1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=NWFAIXPOXVQZQD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11879   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11879(N-Hydroxy-1-(methylsulfonyl)-4-{[4-(phenoxyphenyl]...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11879(N-Hydroxy-1-(methylsulfonyl)-4-{[4-(phenoxyphenyl]...)
Affinity DataKi:  0.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11879(N-Hydroxy-1-(methylsulfonyl)-4-{[4-(phenoxyphenyl]...)
Affinity DataKi:  1nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11879(N-Hydroxy-1-(methylsulfonyl)-4-{[4-(phenoxyphenyl]...)
Affinity DataKi:  800nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed