BDBM119401 US8669361, 220::US9573943, Example 220

SMILES Cn1ncc(NC(=O)c2cncc(n2)-c2ccccc2F)c1N1CCC[C@H](N)CC1

InChI Key InChIKey=YVTVCGFWYNABGD-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 119401   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  22nM ΔG°:  -10.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  22nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  34.2nM ΔG°:  -10.2kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  34.2nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  581nM ΔG°:  -8.50kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

US Patent
LigandPNGBDBM119401(US8669361, 220 | US9573943, Example 220)
Affinity DataKi:  581nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
US Patent