BDBM120395 US8703771, 13::US8703771, 14::US8703771, 8

SMILES CN1CCN(CC1)C1CCc2cc(ccc12)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cncnc2)c1

InChI Key InChIKey=IQOAIXAFDYRGNK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 120395   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  5.30nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  2.40nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  266nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  32nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  65nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  2.26E+3nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120395(US8703771, 13 | US8703771, 14 | US8703771, 8)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In DepthDetails US Patent