BDBM120668 Roche-Dataset for PDE10A, Compound 712::US8703768, 269

SMILES CN(CCO)C(=O)c1ncccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key InChIKey=FJMZJOXFOQKSIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120668   

LigandPNGBDBM120668(US8703768, 269 | Roche-Dataset for PDE10A, Compoun...)
Affinity DataIC50: 12.7nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

LigandPNGBDBM120668(US8703768, 269 | Roche-Dataset for PDE10A, Compoun...)
Affinity DataIC50: 13nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed