BDBM121301 US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide

SMILES CC(C)CN(Cc1cc(Cl)c2OCCCCc2c1)C(=O)C1CCCN(Cc2cccc3ccn(C)c23)C1

InChI Key InChIKey=CTKUJBLIOZDCKM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 121301   

TargetProkineticin receptor 2(Chinese hamster)
University of California

US Patent
LigandPNGBDBM121301(US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)...)
Affinity DataKi:  3nM ΔG°:  -12.1kcal/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetProkineticin receptor 1(Chinese hamster)
University of California

US Patent
LigandPNGBDBM121301(US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)...)
Affinity DataKi:  9.42nM ΔG°:  -11.4kcal/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent