BDBM121427 US8722709, 31

SMILES NC(=O)Nc1cc(CC(c2ccccc2)c2ccccc2)ccn1

InChI Key InChIKey=MTJXSISNDQBYJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 121427   

TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121427(US8722709, 31)
Affinity DataIC50: 13nMpH: 7.4Assay Description:The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121427(US8722709, 31)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at Gal4-fused human MR LBD expressed in HEK293T cells assessed as inhibition of aldosterone-induced transactivation activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121427(US8722709, 31)
Affinity DataIC50: 13nMAssay Description:Displacement of TAMRA-labeled dexamethasone from full-length human mineralocorticoid receptor expressed in baculovirus infected insect cells after 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details Article
PubMed