BDBM123101 US11312693, Example 5::US8735395, 5

SMILES CN1CCN(CC1)c1nc(c(F)s1)-c1ccc(cc1)C(=O)N[C@@H](C1CCCC1)C(=O)N1C[C@@H](C#C)[C@H]2OCC(=O)[C@@H]12

InChI Key InChIKey=DEMUCOOCKQGXOE-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 123101   

TargetCathepsin K(Human)
Medivir

US Patent
LigandPNGBDBM123101(US8735395, 5 | US11312693, Example 5)
Affinity DataKi:  0.600nMAssay Description:Standard assay conditions for the determination of kinetic constants used a fluorogenic peptide substrate, typically H-D-Ala-Leu-Lys-AMC, and were de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetCathepsin K(Human)
Medivir

US Patent
LigandPNGBDBM123101(US8735395, 5 | US11312693, Example 5)
Affinity DataKi:  0.600nMpH: 7.0Assay Description:Standard assay conditions for the determination of kinetic constants used a fluorogenic peptide substrate, typically H-D-Ala-Leu-Lys-AMC, and were de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetProcathepsin L(Human)
Medivir

US Patent
LigandPNGBDBM123101(US8735395, 5 | US11312693, Example 5)
Affinity DataKi:  1.17E+3nMAssay Description:The assay uses baculovirus-expressed human cathepsin S and the boc-Val-Leu-Lys-AMC fluorescent substrate available from Bachem in a 384 well plate fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetCathepsin S(Human)
Medivir

US Patent
LigandPNGBDBM123101(US8735395, 5 | US11312693, Example 5)
Affinity DataKi:  2.90E+3nMAssay Description:The assay uses baculovirus-expressed human cathepsin S and the boc-Val-Leu-Lys-AMC fluorescent substrate available from Bachem in a 384 well plate fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetCathepsin S(Human)
Medivir

US Patent
LigandPNGBDBM123101(US8735395, 5 | US11312693, Example 5)
Affinity DataKi:  2.90E+3nMAssay Description:The assay uses baculovirus-expressed human cathepsin S and the boc-Val-Leu-Lys-AMC fluorescent substrate available from Bachem in a 384 well plate fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent