BDBM124632 US8759366, methyl 4-{difluoro[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]methyl}benzoate

SMILES COC(=O)c1ccc(cc1)C(F)(F)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1

InChI Key InChIKey=XTQUUNMYGNXXJC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124632   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM124632(US8759366, methyl 4-{difluoro[5-(3-methyl-5-{[4-(t...)
Affinity DataIC50:  6.08E+3nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In DepthDetails US Patent