BDBM125051 US8772511, 16::US9714242, 16

SMILES COc1cccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)c1

InChI Key InChIKey=YTFKYVRHCVUFIO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 125051   

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bayer Intellectual Property

US Patent
LigandPNGBDBM125051(US8772511, 16 | US9714242, 16)
Affinity DataKi:  4.30nMpH: 7.4Assay Description:The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bayer Intellectual Property

US Patent
LigandPNGBDBM125051(US8772511, 16 | US9714242, 16)
Affinity DataKi:  15nM ΔG°:  -9.91kcal/molepH: 7.4 T: 2°CAssay Description:Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 3A(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM125051(US8772511, 16 | US9714242, 16)
Affinity DataKi:  2.10E+3nMpH: 7.4Assay Description:Membranes from HEK293 cells which express recombinant human 5-HT3 receptor (RB-HS3, Receptor Biology, Inc., MD, USA) are diluted in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent