BDBM127491 US8791131, 269

SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(CCN4CCOCC4)c3c2n1

InChI Key InChIKey=IVCZYXCKEYXMLR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127491   

LigandPNGBDBM127491(US8791131, 269)
Affinity DataKi:  12.2nM ΔG°:  -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandPNGBDBM127491(US8791131, 269)
Affinity DataKi:  27.8nM ΔG°:  -10.3kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent