BDBM127847 US8791123, 220

SMILES CC(NC(=O)c1cnn2ccc(nc12)N1C(CCC1(C)CO)c1cncc(F)c1)C(F)(F)F

InChI Key InChIKey=JPAYSBNMHYNPLA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127847   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM127847(US8791123, 220)
Affinity DataIC50: 110nMpH: 7.5Assay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharma

US Patent
LigandPNGBDBM127847(US8791123, 220)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
US Patent