BDBM129724 US8815926, 3

SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)-c1ccccc1OC(F)(F)F

InChI Key InChIKey=GPCXWRUJXSUBPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 129724   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129724BDBM129724(US8815926, 3)
Affinity DataIC50: 0.650nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129724BDBM129724(US8815926, 3)
Affinity DataIC50: 703nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent