BDBM129765 US8815926, 44

SMILES CNc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(cc2)C#N)c2cc(Cl)c(=O)n(C)c2)c(OC)n1

InChI Key InChIKey=DMOQEUAEXXWLDJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 129765   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129765BDBM129765(US8815926, 44)
Affinity DataIC50: 0.600nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129765BDBM129765(US8815926, 44)
Affinity DataIC50: 7.80E+3nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent