BDBM129852 US8815926, 131

SMILES COc1ncc(CC#N)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)ccc1C

InChI Key InChIKey=RZQOJXJIASBDHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 129852   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129852BDBM129852(US8815926, 131)
Affinity DataIC50: 1.65nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent