BDBM129975 US8815926, 256

SMILES COC[C@@H](C)n1c(nc2C(=O)N(C(c12)c1ccc(cc1)C#N)c1cccc(Cl)c1F)-c1cnc(OC)nc1OC

InChI Key InChIKey=VFTRVCSLFJWRQT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 129975   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 129975BDBM129975(US8815926, 256)
Affinity DataIC50: 0.280nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent