BDBM130014 US8815926, 296

SMILES CCn1cc(Cl)cc(N2C(c3c(nc(-c4cnc(OC)nc4OC)n3C(C)C)C2=O)c2ccc(Cl)cc2)c1=O

InChI Key InChIKey=PEPZVXADZBSXJG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130014   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 130014BDBM130014(US8815926, 296)
Affinity DataIC50: 0.320nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent