BDBM13080 CGS 27023A Analog 3::N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide::US20230357139, Compound A::US20240050571, Compound NNGH
SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
InChI Key InChIKey=JIRXORZYIXSWOB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 13080
Affinity DataKi: 3.10nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataKi: 132nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
Affinity DataKi: 133nM ΔG°: -9.75kcal/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 174nMAssay Description:Inhibition of MMP1 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Affinity DataKi: 7.40E+3nMAssay Description:Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Affinity DataKi: 7.40E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of MMP7 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of MMP2 using BML-P125-9090 as substrate after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by ChEMBL
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH as substrate preincubated for 60 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of recombinant human MMP2 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant human MMP9 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every min fo...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of MMP-9 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of MMP-2 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of MMP-1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 131nMAssay Description:Inhibition of MMP-13 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 0.590nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-PLGLDpaAR fluorescent substrate incubated for 2 hrs by microplate reader methodMore data for this Ligand-Target Pair
Affinity DataIC50: 612nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
Affinity DataIC50: 202nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of MMP13 (unknown origin) assessed as reduction in cleavage of colorimetric substrate incubated for 1 hr by colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Indian Institute Of Technology (Bhu)
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair