BDBM13245 2-[(butylcarbamoyl)amino]-N-(2-chloro-6-methylphenyl)-4-methyl-1,3-thiazole-5-carboxamide::2-[[(n-Butylamino)carbonyl]-amino]-4-methyl-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 2-Amino-4-methyl-thiazole Analog 8f::CHEMBL130160

SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cccc1Cl

InChI Key InChIKey=WKRXQQRDOWHITL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 13245   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13245(2-[(butylcarbamoyl)amino]-N-(2-chloro-6-methylphen...)
Affinity DataIC50: 620nMAssay Description:Inhibition of CD3/CD28 T-cell proliferation assay in PBL (peripheral blood lymphocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13245(2-[(butylcarbamoyl)amino]-N-(2-chloro-6-methylphen...)
Affinity DataIC50: 620nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed