BDBM135299 US8846657, 5.2

SMILES C[C@@H]1CN(C(=O)C2CC2)CCN1c1nc2cc(-c3noc(=O)[nH]3)nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=IYPCCQZCPSITRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 135299   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135299BDBM135299(US8846657, 5.2)
Affinity DataIC50: 5nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135299BDBM135299(US8846657, 5.2)
Affinity DataIC50: 5nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent