BDBM135952 US8853203, 6::US9650377, Example 6

SMILES COc1cc(ccn1)C1=NCC(=O)N2CCc3c(Cl)cccc3C2=C1

InChI Key InChIKey=WERIHXWXSRLQFO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 135952   

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM135952(US8853203, 6 | US9650377, Example 6)
Affinity DataIC50: 75nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM135952(US8853203, 6 | US9650377, Example 6)
Affinity DataIC50: 75nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM135952(US8853203, 6 | US9650377, Example 6)
Affinity DataIC50: 3.05E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM135952(US8853203, 6 | US9650377, Example 6)
Affinity DataIC50: 3.05E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent