BDBM135984 US8853203, 38::US9650377, Example 38

SMILES O=C1CN=C(C=C2N1CCc1c(cccc21)C#C)c1cccs1

InChI Key InChIKey=JAIOFGJWUSFJQH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 135984   

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM135984(US8853203, 38 | US9650377, Example 38)
Affinity DataIC50: 22nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM135984(US8853203, 38 | US9650377, Example 38)
Affinity DataIC50: 22nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM135984(US8853203, 38 | US9650377, Example 38)
Affinity DataIC50: 50nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM135984(US8853203, 38 | US9650377, Example 38)
Affinity DataIC50: 50nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent