BDBM136715 US10231967, Example 15::US8865911, 15::US9918985, Example 15

SMILES CC1=NC2(N=C1N)c1cc(Br)ccc1CC21CCC(CC1)OC(F)F

InChI Key InChIKey=BIODWENPZVUOJQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 136715   

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM136715(US8865911, 15 | US10231967, Example 15 | US9918985...)
Affinity DataIC50: 46nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandPNGBDBM136715(US8865911, 15 | US10231967, Example 15 | US9918985...)
Affinity DataIC50: 112nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM136715(US8865911, 15 | US10231967, Example 15 | US9918985...)
Affinity DataIC50: 112nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM136715(US8865911, 15 | US10231967, Example 15 | US9918985...)
Affinity DataIC50: 112nMpH: 9.2Assay Description:The beta-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human beta-Secretase (AA 1-AA 460) was clo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2015
Entry Details
US Patent