BDBM136921 US10231967, Example 11::US8865911, 11::US9918985, Example 11

SMILES CC1=NC2(CCOc3ccc(cc23)-c2cc(C)ccc2F)N=C1N

InChI Key InChIKey=MJCNDWZEGNXOEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 136921   

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM136921(US8865911, 11 | US10231967, Example 11 | US9918985...)
Affinity DataIC50: 1.98E+3nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM136921(US8865911, 11 | US10231967, Example 11 | US9918985...)
Affinity DataIC50: 1.98E+3nMpH: 9.2Assay Description:The beta-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human beta-Secretase (AA 1-AA 460) was clo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2015
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandPNGBDBM136921(US8865911, 11 | US10231967, Example 11 | US9918985...)
Affinity DataIC50: 1.98E+3nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent