BDBM141381 US8916600, 15::US8916600, 16::US9738632, Example 16

SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@H]1CCS(=O)C1)c1ccc2COCOc2c1

InChI Key InChIKey=YXBFQFQZZBAMAK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141381   

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141381(US8916600, 16 | US8916600, 15 | US9738632, Example...)
Affinity DataIC50: 3.64nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141381(US8916600, 16 | US8916600, 15 | US9738632, Example...)
Affinity DataIC50: 4.27nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141381(US8916600, 16 | US8916600, 15 | US9738632, Example...)
Affinity DataIC50: 3.64nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141381(US8916600, 16 | US8916600, 15 | US9738632, Example...)
Affinity DataIC50: 4.27nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent