BDBM143338 US8969341, 6

SMILES Cc1cc(Cl)ccc1C1c2c(nn(Cc3cc(=O)[nH]c4c(C#N)cnn34)c2C(C)C)C(=O)N1c1cccc(Cl)c1F

InChI Key InChIKey=VDJFQUDOTQDXAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143338   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 143338BDBM143338(US8969341, 6)
Affinity DataIC50: 18.6nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 143338BDBM143338(US8969341, 6)
Affinity DataIC50: 9.84E+3nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent