BDBM143450 US8969341, 96

SMILES CNC(=O)c1ccc(C)c(c1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C(F)(F)F)c1cc(Cl)ccc1C

InChI Key InChIKey=CRWXYYDAMBWTKL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143450   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 143450BDBM143450(US8969341, 96)
Affinity DataIC50: 5.70nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 143450BDBM143450(US8969341, 96)
Affinity DataIC50: 1.29E+4nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent