BDBM14396 5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 56

SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1

InChI Key InChIKey=AANJEOKXWMXQIE-UHFFFAOYSA-N

Data  2 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14396   

LigandPNGBDBM14396(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1
Show InChI InChI=1S/C23H29N5O4/c1-4-6-17-20-21(27(3)26-17)23(30)25-22(24-20)16-13-15(7-8-19(16)32-5-2)18(29)14-28-9-11-31-12-10-28/h7-8,13H,4-6,9-12,14H2,1-3H3,(H,24,25,30)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

LigandPNGBDBM14396(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1
Show InChI InChI=1S/C23H29N5O4/c1-4-6-17-20-21(27(3)26-17)23(30)25-22(24-20)16-13-15(7-8-19(16)32-5-2)18(29)14-28-9-11-31-12-10-28/h7-8,13H,4-6,9-12,14H2,1-3H3,(H,24,25,30)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair